I went into hibernation and lost a few "friends" along the way but they were people I didn't need around me anyways :)
Be nice. Love with your whole heart. Don't take people and the time you have with them for granted. If you're single, figure out who you are and if you're lucky enough to have someone to call yours, tell them everyday how much you appreciate them. But more importantly, show them. Treat them right. Don't fight.
No fight is worth losing your best friend!